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Journal

Research Journal of Pharmacy and Technology

ISSN:
0974-360X
2
h-index
7
Citations
16
Works
0.00
2-year mean citedness

Trust signals

1 of 3 signals present

Independent positive signals — not a single “predatory/legitimate” verdict, but a converging picture.

  • DOAJ
    No data
    doaj.org
  • OAK list
    No data
    OAK
  • Valid ISSN
    Present
    ISSN

This is an information label, not an official ruling. A missing signal is not a penalty — a regional journal may simply not be in DOAJ.

Trends over time

Performance over time

Citation overview

Publications (bars) and citations (line) by year

  • Publications
  • Citations
0134501345202120232024202520262021: Publications 2, Citations 12023: Publications 1, Citations 22024: Publications 4, Citations 02025: Publications 4, Citations 42026: Publications 5, Citations 0

Citation history

01345202120232024202520262021: Citations 12023: Citations 22024: Citations 02025: Citations 42026: Citations 0

Publication history

01345202120232024202520262021: Publications 22023: Publications 12024: Publications 42025: Publications 42026: Publications 5

h-index evolution

Cumulative h-index by year

012202120232024202520262021: h-index 12023: h-index 12024: h-index 12025: h-index 22026: h-index 2

Most-cited works

  1. The effect of Sulphated cellulose on System of Haemostasis20213 citations
  2. Anti-thrombotic action of sulfated polysaccharides on thrombosis caused by thromboplastin20213 citations
  3. Effects of Polyphenols on changes in the transport of Ca2+ NMDA-receptors under the influence of L-glutamate20231 citations
  4. Wound healing and Antimicrobial properties of extract of the Rumex confertus Willd20240 citations
  5. Correlation Serum Vitamin D with Level of control of Childhood Asthma20240 citations
  6. Hypoazotemic action of dry extracts from the waste of Tribulus terrestris20240 citations
  7. Examining the Interplay of Psychological Factors in Chronic Skin Disease: A Review on Depression, Anxiety, and Stress20240 citations
  8. Correction of mPTP Dysfunction by some Polyphenol extracts20250 citations
  9. Effect of polyphenol YaN-1, a Diazoimino derivative of gossypol, on the membrane of Cardiac Mitochondria20250 citations
  10. Impact of select Polyphenols on α-amylase Activity under In vitro Conditions Khasan Y. Kayumov1*, Lubov S. Kuchkarova1, Jakhongir S. Abdurakhmonov1, Rashidbek Kh. Achilov1, Shoaib Khan2, Teodoro Durá-Travé3, Manzura A. Agzamova4, Komila A. Eshbakova4, Shohista O. Meliyeva4, Nedim Özdemir5, Anum Masood6 1National University of Uzbekistan named after Mirza Ulugbek, Tashkent, Uzbekistan. 2Department of Chemistry, Abbottabad University of Science and Technology, Abbottabad - 22500, Pakistan. 3Faculty of Medicine, University of Navarra, Spain. 4Institute of Chemistry of Plant Substans of the Academy of Sciences of Uzbekistan, Tashkent, Uzbekistan. 5Mugla Sıtkı Kocman University, Turkey. 6Department of Pharmaceutical Chemistry, The Islamia University of Bahawalpur Pakistan, Bahawalpur, Pakistan. *Corresponding Author E-mail: [email protected] ABSTRACT: Background: Flavonoids have been extensively researched for their ability to modulate enzyme activity, particularly in relation to controlling blood sugar and carbohydrates metabolism. However, there is limited information on the tissue-specific effects of structurally diverse flavonoids on α-amylase activity. This study aimed to investigate and compare rutin, quercetin, luteolin, chrysosplenetin, and thamiflaside affects on α-amylase activity in various parts of the digestive system. Methods: We used homogenates from pancreatic tissue, parotid gland, intestinal mucosa, and chyme during in vitro assays. Flavonoids were tested at different levels and α-amylase activity was measured using a spectrophotometer. The Student-Fisher t-test was used to run a statistical analysis to determine dose and tissue-dependent effects. Results: Rutin, quercetin, luteolin, and chrysosplenetin significantly and dose-dependently inhibited the α-amylase activity. The parotid gland and intestinal mucosa were more sensitive (p<0.05). Luteolin had the strongest inhibitory impact, perhaps because of its hydroxylation patterns. On the other hand, thamiflaside had a distinct influence on α-amylase activity, particularly in the salivary and intestinal compartments suggesting allosteric activation pathways. The varied modulatory profiles were correlated with flavonoid structure-function relationships, where the distribution of hydroxyl and methoxyl groups determines the enzyme binding and outcomes. Conclusion: The results showed that some flavonoids might be used as natural α-amylase inhibitors to regulate blood sugar levels and treat metabolic disorders. They also showed that thamiflaside could help those who need better carbohydrate digestion. These findings revealed that flavonoids might be added to nutraceutical formulations in an organized way. Furthermore, in vivo and clinical studies are needed to determine their safety and efficacy as therapeutic agents. KEYWORDS: Flavonoids, α-Amylase, Rutin, Quercetin, Luteolin, Chrysosplenetin, Thamiflaside, Enzyme Modulation, Glycemic Control, Digestive Enzymes.20250 citations
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